An isoketal scavenger
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2-HOBA

Item No. 25357

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(aminomethyl)-phenol
CAS Number
932-30-9
Synonyms
  • 2-(Aminomethyl)phenol
  • 2-Hydroxybenzylamine
  • NSC 127870
Molecular Formula
C7H9NO
Formula Weight
123.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
201, 216, 276 nm
SMILES
OC1=C(CN)C=CC=C1
InChi Code
InChI=1S/C7H9NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H,5,8H2
InChi Key
KPRZOPQOBJRYSW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $49

    Add

    500 mg

    $93

    Add

    1 g

    $171

    Add

    5 g

    $748

    Add
    Product Description

    2-HOBA is an isoketal scavenger.1 In vivo, 2-HOBA reduces angiotensin II-induced increases in blood pressure and decreases isoketal accumulation in mouse heart and vasculature. It also prevents angiotensin II-induced collagen IV accumulation and renal damage in mouse kidney. 2-HOBA has also been used as a building block in the synthesis of saluretic agents and task-specific ionic liquids.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kirabo, A., Fontana, V., de Faria, A.P.C., et al. DC isoketal-modified proteins activate T cells and promote hypertension. J. Clin. Invest. 124(10), 4642-4656 (2014).

    2. Stokker, G.E., Deana, A.A., deSolms, S.J., et al. 2-(Aminomethyl)phenols, a new class of saluretic agents. 3. Effects of functional group reorientation and modification. J. Med. Chem. 24(9), 1063-1067 (1981).

    3. Ouadi, A., Gadenne, B., Hesemann, P., et al. Task-specific ionic liquids bearing 2-hydroxybenzylamine units: Synthesis and americium-extraction studies. Chemistry 12(11), 3074-3081 (2006).

    Product Citations

    Gokulan, R.C., Paulrasu, K., Azfar, J., et al. Protein adduction causes non-mutational inhibition of p53 tumor suppressor. Cell Rep. 42(1), 112024 (2023).

    Pitzer, A., Elijovich, F., Laffer, C.L., et al. DC ENaC-dependent inflammasome activation contributes to salt-sensitive hypertension. Circ. Res. 131(4), 328-344 (2022).